Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5276430 | Tetrahedron Letters | 2012 | 5 Pages |
Abstract
A facile synthesis of a wide variety of tert-butyl ethers and tert-butyl ester derivatives under mild conditions is described. Alcohols etherified with tert-butyl methyl ether as tert-butyl source and solvent, in the presence of sulfuric acid. Many amino acid tert-butyl esters have been synthesized by this procedure. The reaction is simple, inexpensive, easily scaled up, and proceeds without observable racemization. A green method was developed for the deprotection of this group using Amberlite resin IR 120-H as catalyst.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
N. Mallesha, S. Prahlada Rao, R. Suhas, D. Channe Gowda,