| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5276436 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
Novel thermolabile hydroxyl protecting groups of increased thermostability are proposed. The stability of these groups at different temperatures ranges has been determined. The 2-pyridyl-N-(2,4-difluorobenzyl)aminoethyl unit was selected as stable at ambient temperature and very labile at increased temperature. The half-life times for the best groups were established. Application of this chemistry to the protection of different hydroxyl groups of thymidine was also demonstrated.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marcin K. Chmielewski,