| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5276488 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Ketones 1 were converted to α-quaternary α-vinyl ketones 2 by a two-step formal allylic carbon insertion between ketone carbonyl and α carbons, which involves the reaction of 1 with propargyltitanium reagents, derived from propargyl carbonates 3 and a divalent titanium reagent Ti(O-i-Pr)4/2i-PrMgCl, and the following rearrangement of the resulting α-allenyl alcohols 4 with NBS.
Graphical abstractKetones 1 were converted to α-quaternary α-vinyl ketones 2 by reaction with propargyltitanium reagents, derived from propargyl carbonates 3 and a divalent titanium reagent, followed by rearrangement of the resulting α-allenyl alcohols 4 with NBS.Download full-size image
Related Topics
Physical Sciences and Engineering
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Authors
Jing-Qian He, Daisuke Shibata, Chihaya Ohno, Sentaro Okamoto,