Article ID Journal Published Year Pages File Type
5276506 Tetrahedron Letters 2007 4 Pages PDF
Abstract

8-Methyl-3,8-diazabicyclo[3.2.1]octane (3-azatropane) is synthesized efficiently from pyroglutamic acid making use of amide activation. The key step of the synthesis involves reduction and cyclization of a nitroenamine intermediate. Several 3-substituted analogues of this azatropane were also synthesized via this methodology and evaluated for their affinity at D2 and 5-HT2A receptors.

Graphical abstractA convenient and efficient synthesis of 8-methyl-3,8-diazabicyclo[3.2.1]octane is reported.Download full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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