Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5276506 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
8-Methyl-3,8-diazabicyclo[3.2.1]octane (3-azatropane) is synthesized efficiently from pyroglutamic acid making use of amide activation. The key step of the synthesis involves reduction and cyclization of a nitroenamine intermediate. Several 3-substituted analogues of this azatropane were also synthesized via this methodology and evaluated for their affinity at D2 and 5-HT2A receptors.
Graphical abstractA convenient and efficient synthesis of 8-methyl-3,8-diazabicyclo[3.2.1]octane is reported.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rakesh K. Singh, Sanjay Jain, Neelima Sinha, Anita Mehta, Fehmida Naqvi, Ashok K. Agarwal, Nitya Anand,