Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5276559 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
In search for new methods aiming biomimetic synthesis of polyprenylated acylphloroglucinols (PPAPs), we now report the results of an evaluation of sulfonium salts as prenyl, geranyl, and isolavandulyl transfer agents towards benzoylphloroglucinol derivatives, in neutral conditions. As a result, conditions were found for rather efficient C-prenylation of these compounds. The corresponding trimethyl ether gave the best results, but the reaction was accompanied by a deacylation process. Geranyl transfer was also observed, but in low yield, and, interestingly, an isolavandulyl group could be introduced with an appreciable yield.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Solenn Brajeul, Bernard Delpech, Christian Marazano,