| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5276600 | Tetrahedron Letters | 2010 | 5 Pages |
Abstract
A novel approach to skeletally diverse 3-oxoisoindolines has been developed which includes preparation of Ugi adducts containing thiophene and fumaric acid residues. When treated with excess m-CPBA at room temperature, these precursors undergo a simple oxidative cycloaddition/aromatization transformation and the corresponding 3-oxoisoindoline products are isolated in fair chemical yield over two steps. The second step is thought to include S-oxidation/IMDA/S-oxidation/SO2 extrusion/aromatization events.
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Mikhail Krasavin, Vadislav Parchinsky,