Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5276602 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
A general method for the kinetic resolution of racemic α-arylalkanoic acids with achiral alcohols is described. It was determined that bis(9-phenanthryl)methanol is a suitable nucleophile which reacts with the intermediary mixed anhydrides generated from aromatic anhydrides with α-arylpropanoic acids or β-substituted-α-arylpropanoic acids in the presence of (+)-benzotetramisole to produce the corresponding optically active esters with high ee's under very mild conditions.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kenya Nakata, Yu-suke Onda, Keisuke Ono, Isamu Shiina,