| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5276636 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
The stereoselective syntheses of pyrrolidine-fused aspartate and glutamate analogs, (S)-α-carboxymethyl-proline 3 and (S)-α-2-carboxyethyl-proline 4, using a chirality-transferring ester-enolate Claisen rearrangement of α-vinyl-α-acyloxysilane having a Boc-Pro as an acyloxy group, are described. The stereochemical outcome of the proline ester-derived ester-enolate Claisen rearrangement is also disclosed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kazuhiko Sakaguchi, Masahiro Yamamoto, Yusuke Watanabe, Yasufumi Ohfune,