| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5276653 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A novel version of the Biginelli reaction using an unprotected aldose as a biorenewable aldehyde component and 2-methyl-2-phenyl-1,3-oxathiolan-5-one as a mercaptoacetylating active methylene building block with urea/thiourea is reported. The reaction is nanoclay-catalysed, expeditious and effected under solvent-free microwave irradiation conditions in a one-pot procedure to yield diastereoselectively, thiosugar-annulated multifunctionalized dihydropyrimidines via intramolecular domino cyclocondensation reactions of an isolable intermediate.
Related Topics
Physical Sciences and Engineering
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Authors
Lal Dhar S. Yadav, Chhama Awasthi, Vijai K. Rai, Ankita Rai,