| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5276709 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
The total synthesis of haminol A has been completed featuring a masked-alkene metathesis reaction followed by bis-acyloxysulfone elimination to install the 1,3,8-triene subunit. During the course of our synthesis, the metathesis reactivity of 3-vinylpyridine was evaluated and our data suggest the rapid formation of a ruthenium pyridylalkylidene that no longer participates in productive metathesis. A chemotaxis assay using Caenorhabditis elegans demonstrated that haminol A produced an avoidance response from this organism.
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Related Topics
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Organic Chemistry
Authors
Jennifer M. Storvick, Evgenia Ankoudinova, Brianne R. King, Heather Van Epps, Gregory W. O'Neil,