| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5276792 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
The cross-coupling of aromatic and aliphatic acyl chlorides with arylboronic acids in the presence of 2.5 mol % of (t-Bu2POH)2PdCl2 (POPd) provides rapid access to ketones that are obtained in up to 93% yield. This palladium-phosphinous acid-catalyzed reaction is completed within 10 min when microwave irradiation is used, and it overcomes typical drawbacks of Friedel-Crafts acylation procedures such as harsh reaction conditions, untunable regiocontrol, and low substrate scope.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kekeli Ekoue-Kovi, Hanhui Xu, Christian Wolf,