| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5276796 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
The synthesis of tricyclic lactam building blocks by the radical addition-cyclization-elimination (RACE) reaction is presented. A range of oxime ethers carrying unsaturated ester part have been tested for the radical reaction. A variety of substituents were incorporated around the aromatic backbones and their effect on the RACE reaction has been examined. In addition, the power of RACE reaction is demonstrated by preparation of a key intermediate for the synthesis of constrained analogue of methoctramine.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Habibur Rahaman, Atsushi Shirai, Okiko Miyata, Takeaki Naito,