| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5276831 | Tetrahedron Letters | 2007 | 5 Pages |
Abstract
A simple and efficient synthesis of polystyrene-supported proline and prolinamide has been carried out. Polystyrene-supported proline has been used as organocatalyst in the asymmetric aldol reaction between cyclohexanone and substituted benzaldehydes in water without any additive. High yields, diastereoselectivities and ee values have been observed. The versatility of this resin was demonstrated in the α-selenenylation of aldehydes. Both proline and prolinamide resins gave high yields. Recycling studies showed that the proline resin gave better results than prolinamide resin.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Francesco Giacalone, Michelangelo Gruttadauria, Adriana Mossuto Marculescu, Renato Noto,