| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5276857 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
N,N-Diphenyl-α-haloacetamides undergo Darzens condensations with aldehydes under heterogeneous reaction conditions in the presence of a metal hydroxide base. By appropriate choice of solvent, base and halide, very high diastereoselectivities favouring formation of the cis- or trans-epoxide can be obtained.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thierry J.R. Achard, Yuri N. Belokon', Jamie Hunt, Michael North, Francesca Pizzato,