| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5276858 | Tetrahedron Letters | 2007 | 5 Pages |
Abstract
A cobalt(salen) complex has been shown to catalyse the asymmetric Darzens condensation between α-haloamides and aldehydes, allowing both the relative and absolute stereochemistry of the epoxy-amide products to be controlled. Under optimal conditions, cis-epoxides can be obtained diastereoselectively with up to 50% enantiomeric excess, whilst by changing the leaving group and base, trans-epoxides can be produced diastereoselectively with up to 43% enantiomeric excess.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thierry J.R. Achard, Yuri N. Belokon', Michael Ilyin, Margarita Moskalenko, Michael North, Francesca Pizzato,