Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5276875 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A highly efficient one-pot, two-step microwave procedure has been developed for the synthesis of 4-substituted 1-heteroarylpiperazines. Microwave heating of heteroaryl chlorides with 1,4-diazabicyclo[2.2.2]octane (DABCO) at 160 °C for 15 min yielded 1-heteroaryl-4-(2-chloroethyl)piperazines, which could be further reacted with various nucleophiles, again under microwave irradiation conditions, to give an array of 4-substituted 1-heteroarylpiperazines in good to excellent yields.
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Authors
Hong-Jun Wang, William G. Earley, Robert M. Lewis, Rajiv R. Srivastava, Andrew J. Zych, David M. Jenkins, David J. Fairfax,