Reaction of N,N-disubstituted perfluoroalkanethioamides with trialkyl phosphites. A new method for the synthesis of polyfluorinated α-aminophosphonates

The first examples of the reactions of perfluoroalkanethiocarboxylic acid amides and trialkyl phosphites are presented. The reactions are shown to be dependent on the perfluoroalkyl chain length and the presence of proton-donating reagents. New fluorinated α-aminophosphonate derivatives are obtained in moderate to good yields.

Graphical abstractThe reactions of perfluoroalkanethiocarboxylic acid amides with trialkyl phosphites afford saturated and unsaturated α-aminophosphonates.Download full-size image