Article ID Journal Published Year Pages File Type
5276969 Tetrahedron Letters 2008 4 Pages PDF
Abstract
Aldehydes undergo smooth nucleophilic addition with 2-trimethylsilyloxyfuran in the presence of 10 mol % of iodine under mild and neutral conditions to produce the corresponding δ-silyloxy-α,β-unsaturated-γ-lactones in high yields and with moderate diastereoselectivity. ortho-Substituted benzaldehydes afford the syn-isomer predominantly. The use of iodine makes this procedure quite simple, more convenient and cost-effective.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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