Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5276969 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Aldehydes undergo smooth nucleophilic addition with 2-trimethylsilyloxyfuran in the presence of 10 mol % of iodine under mild and neutral conditions to produce the corresponding δ-silyloxy-α,β-unsaturated-γ-lactones in high yields and with moderate diastereoselectivity. ortho-Substituted benzaldehydes afford the syn-isomer predominantly. The use of iodine makes this procedure quite simple, more convenient and cost-effective.
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Authors
J.S. Yadav, B.V.Subba Reddy, G. Narasimhulu, G. Satheesh,