Synthetic studies toward the PPAP natural products, prolifenones A and B and hyperforin: an Effenberger cyclization approach

A synthetic approach toward the geranylated PPAP natural products, prolifenones A and B, employing Effenberger cyclization as the key step, is delineated. The efficacy of this approach is further expanded through access to an advanced precursor of hyperforin.

Graphical abstractDownload full-size image