Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5277030 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
A novel route to 12 substituted 2-amino-4-quinazolinones is described. Starting from 2,6-difluoro-4-methoxybenzonitrile, substitution of one of the fluorine atoms either directly or indirectly with heterocycles (e.g., pyridyl, thiazolyl, pyrazolyl) followed by hydrolysis of the nitrile gave a series of o-fluorobenzoic acid derivatives. Condensation with a set of six N,N-disubstituted guanidines followed by base-promoted ring closure afforded 2-amino-4-quinazolinone derivatives.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
M. Jonathan Fray, John P. Mathias, Carly L. Nichols, Yvonne M. Po-Ba, Hayley Snow,