| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5277043 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
Si(0)/KF is introduced as a strong, inexpensive, environmentally friendly, and safe reagent for 'dissolving metal'-type reduction. PMHS/hexamethyldisiloxane/pTSA is introduced as an inexpensive substitute for Et3SiH/TFA for 'ionic hydrogenation', where the hexamethyldisiloxane functions as a capping agent to block the oligomeric silicone by-product from cross-linking to a gel, rubber, or plastic. An environmentally friendly and cost effective synthesis of estradiol is described which showcases these new reagents.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chongsoo Lim, Gerald N. Evenson, William R. Perrault, Bruce A. Pearlman,