| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5277046 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
A new ROMP-derived scavenging reagent, oligomeric phosphonyl dichloride (OPC), with high-load and selectivity is reported. This reagent can be readily generated via the ROM polymerization of bicyclo[2.2.1]hept-5-en-2-ylphosphonic dichloride, which is conveniently assembled from the Diels-Alder reaction of cyclopentadiene and vinyl phosphonic dichloride. The OPC has been exploited in the rapid, efficient scavenging of primary and secondary amines that are present in excess following a common benzoylation event at room temperature (30-60Â min) or under microwave conditions in shorter duration (<5Â min).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Russell H. Herpel, Punitha Vedantham, Daniel L. Flynn, Paul R. Hanson,