| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5277067 | Tetrahedron Letters | 2007 | 5 Pages |
Abstract
Enantioselective synthesis of constrained trans-aminobenzazepinone utilizing palladium-mediated Jeffery-Heck reaction and rhodium(II) catalyzed asymmetric hydrogenation as key steps are described. Diverse functional groups such as alkyl, aryl, basic or amino acid moieties were introduced with minimal racemization.
Graphical abstractConstrained trans-aminobenzazepinones (8a-e) were synthesized through a tandem palladium-mediated Jeffery-Heck reaction and rhodium(II) catalyzed asymmetric hydrogenation. Diverse functionalities were introduced at the amino terminus of aminobenzazepinone with minimal racemization.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
C.V.C. Prasad, Stephen E. Mercer, Gene M. Dubowchik, John E. Macor,