| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5277114 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
A practical Sonogashira alkynylation protocol for the preparation of 8-alkynylated adenosines and guanosines has been developed. Protection of the sugar hydroxyl substituents is not required; protection hinders the purification of these products. A preliminary fluorescent study is reported, which shows that the presence of a substituent on the phenylene ring influences the fluorescent properties considerably, an outcome that could be utilized in biological applications.
Graphical abstractÏ-Conjugated linear acetylenes attached to guanosine and adenosines have been prepared.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrew G. Firth, Ian J.S. Fairlamb, Kate Darley, Christoph G. Baumann,