| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5277145 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
The highly enantioselective hydrogenation of methyl 4-tert-butylcarbamoyl-3-oxo-butyrate to the corresponding secondary alcohol, representing an interesting chiral building block, for example, for the synthesis of statins, has been investigated in the presence of homogeneous chiral Rh(I) and Ru(II) complexes bearing phosphine ligands. The highest enantioselectivity (up to 96%) was achieved with a [Ru((R)-BINAP)(p-cymene)Cl]Cl complex (sub./cat. ratio 100:1, 5Â bar H2, rt, MeOH).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vasyl Andrushko, Natalia Andrushko, Gerd König, Armin Börner,