Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5277179 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
A new submonomeric approach for the Fmoc solid phase synthesis of chiral PNAs is reported here. The design and synthesis of a new d-lysine-based Fmoc submonomer obtained by replacing the nucleobase residue with an Alloc group, compatible with Fmoc chemistry, is described starting from d-lysine and Fmoc-aminoacetaldehyde. The desired submonomer was obtained in high yield with no racemization. The conditions for synthesizing a chiral PNA dimer on solid support by a submonomeric approach have been optimized, allowing to obtain the desired PNA with a very high optical purity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tullia Tedeschi, Stefano Sforza, Francesca Maffei, Roberto Corradini, Rosangela Marchelli,