Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5277224 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
A short and practical procedure for the preparation of C-2 substituted polyhydroxypyrrolidines is described. The C-2 substituent is introduced by a stereoselective addition of a Grignard reagent to a 2,3,5-protected aldofuranose and the cyclization to the pyrrolidine ring system is performed through a bis-mesylation/double nucleophilic displacement sequence. The efficiency of the methodology was demonstrated by its application to the synthesis of HomoDMDP and DMDP.
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Chemistry
Organic Chemistry
Authors
Jean-Bernard Behr, Georges Guillerm,