Total synthesis of the fungal metabolite (±)-acremine G: acceleration of a biomimetic Diels–Alder reaction on silica gel

A total synthesis of the bioactive tetracyclic natural product acremine G has been achieved in which a regio- and stereoselective biomimetic Diels–Alder reaction between two readily assembled building blocks, accelerated on a solid support (silica gel), forms the key step.

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