| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5277299 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
Oligodeoxynucleotides acylated with a 2-(trimethylsilyl)benzoyl (TMSBz) group at the 5â² or 3â² terminus were synthesized according to the general method used for DNA synthesis. The acylated DNA oligomers could be easily purified due to the high lipophilicity of the TMSBz group and showed enhanced hybridization ability and resistance to exonucleases.
Graphical abstractOligonucleotides acylated by the chemically stable TMSBz group at their 5â² or 3â² terminus were synthesized. This modification enhanced not only their resistance to exonucleases but also hybridization affinity for the complementary DNA oligomers.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ken Yamada, Haruhiko Taguchi, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine,