| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5277338 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
The palladium-catalyzed α-arylation of ketones on solid support is described. Using modified Buchwald-Hartwig reaction conditions, the coupling of immobilized 4-bromobenzamide with various aromatic, heteroaromatic, and aliphatic ketones was investigated. Subsequent cleavage from the resin provided the desired α-aryl ketones almost in moderate to high yields and good to excellent purities. The scope and limitations of this protocol will be discussed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marcus Limbeck, Heinrich Wamhoff, Thomas Rölle, Nils Griebenow,