Aminomethylation of chiral silyl enol ethers: access to β2-homotryptophane and β2-homolysine derivatives

We describe here the aminomethylation of chiral silyl enol ether derivatives using iminium ion. The choice of judicious precursors with adequate protecting groups for the silylation/aminomethylation step was required to achieve the synthesis of β2-homotryptophane in few steps. The same methodology was used to prepare a β2-homolysine derivative.

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