| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5277556 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
The synthesis and asymmetric Birch reduction-alkylation of chiral benzamide 17 are described. Birch reductive alkylation of benzamide 17 was optimized to give the corresponding cyclohexa-1,4-diene products in 66-78% isolated yield and with high diastereoselectivity (dr: >98:2). The effects of performing the reduction in the presence and in the absence of tert-butyl alcohol are discussed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Agustin Casimiro-Garcia, Arthur G. Schultz,