| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5277678 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
Asmarines are tetrahydro[1,4]diazepino[1,2,3-g,h]purine derivatives isolated from marine sponges (Raspailia sp). They possess profound cytotoxic activity towards cancer cell lines, and are thus attractive synthetic targets. The tetrahydrodiazepinopurine ring skeleton has been prepared employing the RCM reaction on Boc-protected 6-allylamino-7-(propen-1-yl)purine as the key step for the construction of the seven-membered ring. 7-(Propen-1-yl)purines were formed by a novel rearrangement of 7-allylpurines under basic conditions. Boc-protected N6,7-diallylpurine also participated in RCM to give the eight-membered ring analog of the diazepinopurine.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anders Vik, Lise-Lotte Gundersen,