| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5277775 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
The addition of Grignard reagents to chiral trifluoromethyl tert-butyl sulfinimine–ethanol adducts affords protected trifluoromethylamines in high yields with good to excellent diastereoselectivities. The stereochemical outcome of the addition is opposite to that expected via a chelation controlled transition state.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
