| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5277781 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
A new convenient route to enantiopure 2-coumarinyloxypropanals is described: Rosenmund reduction of (R)- or (S)-2-coumarinyloxypropanoyl chlorides afforded in good yields the corresponding 2-coumarinyloxypropanals. Their subsequent aldolic condensation with 3(2H)-furanones, followed by dehydration, led to enantiopure geiparvarin analogues now being investigated as promising antitumoral compounds.
Graphical abstractThe synthesis of enantiopure 2-coumarinyloxypropanals is described.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stefano Chimichi, Marco Boccalini, Giancarlo Cravotto, Ornelio Rosati,