Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5277823 | Tetrahedron Letters | 2008 | 5 Pages |
Abstract
Tonkinensines A (1) and B (2), two novel cytisine-type alkaloids that feature the skeleton with a linkage to pterocarpan, were isolated from the roots of Sophora tonkinensis. Their structures and absolute configurations were elucidated by spectroscopic methods, especially X-ray crystal diffraction and CD spectral analysis. The proposed biosynthetic pathway was also discussed. Both 1 and 2 were tested in HeLa and MDA-MB-231 tumor cell lines, and compound 2 showed moderate cytotoxic activity.
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Authors
Xing-Nuo Li, Zhi-Qiang Lu, Song Qin, Hai-Xia Yan, Min Yang, Shu-Hong Guan, Xuan Liu, Hui-Ming Hua, Li-Jun Wu, De-An Guo,