| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5277906 | Tetrahedron Letters | 2007 | 4 Pages |
Abstract
An enantioselective organocatalytic inverse electron demand hetero Diels-Alder reaction of in situ generated enamines with o-quinone reagents is reported. The method, which is optimal in wet acetonitrile at ambient temperature, provides a new and direct asymmetric route to the aryl alkyl ether motif and an alternative metal-free strategy to SN2 substitutions with phenolate nucleophiles.
Graphical abstractAn enantioselective organocatalytic inverse electron demand hetero Diels-Alder reaction of in situ generated enamines of aldehydes with ortho-quinone reagents is reported.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
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Authors
Felix A. Hernandez-Juan, Dane M. Cockfield, Darren J. Dixon,