| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5277940 | Tetrahedron Letters | 2011 | 5 Pages |
Abstract
Exploratory studies towards the preparation of potential HIV-1 protease and integrase inhibitors have led to the synthesis of Baylis-Hillman-derived N,Nâ²-disubstituted piperazines. X-ray crystallographic, computer modelling and NMR techniques have been used to elucidate questions concerning configurational preferences, reaction pathways and the apparent difference in susceptibility towards aza-Michael reactions exhibited by methyl acrylate and methyl vinyl ketone (MVK) derived Baylis-Hillman substrates.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kenudi C. Idahosa, Yi-Chen Lee, Dubekile Nyoni, Perry T. Kaye, Mino R. Caira,