Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5277943 | Tetrahedron Letters | 2011 | 6 Pages |
Abstract
An efficient one-pot procedure for the regioselective synthesis of (Z)-3-(halomethylene)-isoindolin-1-ones was developed from easily accessible 2-(2,2-dihalovinyl)benzonitriles. From this key intermediate, a variety of isoindolinones containing an enyne moiety were synthesized in good to excellent yields via palladium-catalyzed Sonogashira reaction. The generated enyne-containing isoindolinones could be further manipulated by iodide induced cyclization reaction to afford a versatile synthetic intermediate 5H-pyrrolo[2,1-a]isoindolol-5-one in high yield and could be further elaborated.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chengming Wang, Caiyun Sun, Fei Weng, Mingchun Gao, Bingxin Liu, Bin Xu,