Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5277948 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
First asymmetric synthesis of (â)-chicanine has been accomplished in 14 steps by employing the Evans asymmetric syn-selective aldol reaction, diastereoselective hydroboration and an regioselective, intramolecular Mitsunobu etherification. The absolute configuration of (+)- and (â)-chicanine has been revised to 2R,3S,4R,5R and 2S,3R,4S,5S, respectively, through CD analysis.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kenichi Harada, Hiroki Horiuchi, Kazuma Tanabe, Rich G. Carter, Tomoyuki Esumi, Miwa Kubo, Hideaki Hioki, Yoshiyasu Fukuyama,