Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5278018 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
The first total synthesis of polygalatenosides A (1) and B (2), originally isolated from the traditional Chinese medicine and reported as antidepressant agents, is described here. Glycosylation between thiogalactosyl donors 6 and 7 and 1-deoxyglucosyl acceptor 5 yielded the corresponding key intermediates 10 and 16, respectively, with an α(1â2)-glycosidic linkage in moderate yields. In addition, d-configuration of the galactoside residue in 1 and 2 was confirmed in our studies.
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Authors
Chih-Ming Huang, Rai-Shung Liu, Tian-Shung Wu, Wei-Chieh Cheng,