| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5278022 | Tetrahedron Letters | 2008 | 5 Pages |
Abstract
A new erythromycin A derivative (9-tritylhydrazone) is described and easily transformed into clarithromycin by regioselective O-methylation at C(6)-OH. Conformational analysis based on X-ray diffraction, 1H NMR data and molecular mechanic calculations was aimed to understand the observed high regioselectivity. The facile synthesis of 6,12-O-dimethylerythromycin A is also reported.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ernesto Brunet, Francisco Parra, Susana Mantecón, Olga Juanes, Juan Carlos RodrÃguez-Ubis, Ma Carmen Cruzado, Ramón Asensio,