Article ID Journal Published Year Pages File Type
5278141 Tetrahedron Letters 2006 5 Pages PDF
Abstract

A convenient cyclization method leading to trisubstituted imidazoles in up to 84% yield is reported. Diverse 1-aryl-, 2-heteroaryl-substituted ethanones are converted into the corresponding α-oximino derivatives which are reduced under regioselective conditions. The obtained α-amino carbonyl intermediates are reacted with alkyl- or arylalkyl thiocyanates to directly yield C2-S-substituted imidazoles.

Graphical abstractCyclization with substituted thiocyanates.Download full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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