Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5278141 | Tetrahedron Letters | 2006 | 5 Pages |
Abstract
A convenient cyclization method leading to trisubstituted imidazoles in up to 84% yield is reported. Diverse 1-aryl-, 2-heteroaryl-substituted ethanones are converted into the corresponding α-oximino derivatives which are reduced under regioselective conditions. The obtained α-amino carbonyl intermediates are reacted with alkyl- or arylalkyl thiocyanates to directly yield C2-S-substituted imidazoles.
Graphical abstractCyclization with substituted thiocyanates.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stefan A. Laufer, Andy J. Liedtke,