| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5278169 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
Acetylenedicarbaldehyde, a desirable but intractable C4 synthon, can be protected as the Gorgues’ dicobalt hexacarbonyl complex. It undergoes chimio-, diastereo- and enantioselective attack of terminal alkynes using zinc triflate and (−)-N-methyl-ephedrine to afford stable complexes of chiral secondary carbinol-skipped oligoynes.
Graphical abstractThe Carreira’s procedure has been adapted to the sensitive C4 synthon of high functional density, to afford chiral secondary carbinol-skipped oligoyne complexes.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
