| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5278197 | Tetrahedron Letters | 2006 | 4 Pages |
Abstract
We achieved the total synthesis of the histone deacetylase inhibitor spiruchostatin A, as the prelude to the preparation of a combinatorial library of its analogues. Two key reactions were an asymmetric acetate aldol reaction using a Zr-enolate and macrolactonization using the Shiina method.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takayuki Doi, Yusuke Iijima, Kazuo Shin-ya, A. Ganesan, Takashi Takahashi,