Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5278220 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Five new isothiocyanate sesquiterpenes, designated axiplyns A-E (1-5) have been isolated, together with two known isothiocyanate sesquiterpenes (6, 7), from the sponge Axinyssa aplysinoides collected at Misali Island, Tanzania. Axiplyns 4 and 5 embody a new indane sesquiterpene skeleton, and compounds 1, 2, and 5 contain unprecedented ring systems, namely a 6,8-dioxabicyclo[3.2.1]octane and a 2-oxabicyclo[2.2.1]heptane. Axiplyns A, B, and C are potent brine shrimp toxins with LD50 values between 1.5 and 1.8 μg/mL.
Related Topics
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Authors
Hagit Sorek, Ayellet L. Zelikoff, Yehuda Benayahu, Yoel Kashman,