Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5278231 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Highly diastereoselective aldol-type condensations induced by the chiral magnesium enolate of tert-butyl p-tolyl sulfinyl acetate were performed with optically pure alkyl or hydroxy α-substituted aldehydes. The addition of chiral α-sulfinyl acetate to various aldehydes, α-substituted or not, results mainly with a syn stereochemistry of the two newly created stereocenters. Applications were investigated for the synthesis of syn and trans 1,2-diol models and polysubstituted precursor for natural products.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Claude Bauder,