| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5278250 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
A substituted hydropyrazino[1,2-a]pyrimidin-6-one derivative was synthesized stereoselectively via the intramolecular N-acyliminium ion cyclization between an amide nitrogen and an Nα-acetal derived from Cbz-protected aminopropyl-phenylalaninamide in very good yields. The formation of a single diastereomer is due to the low energy chairlike conformation of its bicyclic structure. This methodology provides a convenient tool to build internal bicyclic peptidomimetics.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis of a novel benzyl-octahydropyrazino[1,2-a]pyrimidin-6-one derivative as a convenient internal bicyclic peptidomimetic](/preview/png/5278250.png "First Page Preview: Synthesis of a novel benzyl-octahydropyrazino[1,2-a]pyrimidin-6-one derivative as a convenient internal bicyclic peptidomimetic")