Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5278321 | Tetrahedron Letters | 2011 | 5 Pages |
Abstract
Pseudouridine (Ï-uridine, Ψ) azaâ²-analogues with a 5,5-bis(hydroxymethyl)-1-pyrrolin-2-yl 1-oxide as the glycone mimic were obtained by the addition of (2,4-dimethoxypyrimidin-5-yl)magnesium bromide to 1-aza-7,14-dioxadispiro[4.2.5.2]pentadec-1-ene 1-oxide (3), followed by oxidation and removal of the protecting groups. The analogous synthesis from (2,4-dimethoxypyrimidin-5-yl)lithium and 3 was less efficient; in the first step of the reaction sequence, competing dimerisation of 3 predominated over addition of the organolithium agent to 3.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mariola Koszytkowska-StawiÅska, Ewa Mironiuk-Puchalska, Wojciech Sas,