| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5278400 | Tetrahedron Letters | 2006 | 6 Pages |
Abstract
N,N-Bis(perfluoroalkyl)thiocarbamoyl chlorides (FDMTC-Cls) were synthesized as reagent for the protection of alcohols. Using the crystalline FDMTC-Cls, the FDMTC groups were introduced into the alcohol molecules in excellent yields in the presence of sodium hydride in THF at room temperature. The products were separated from the excess alcohols by solid-phase extraction with a fluorous reverse-phase silica gel column (Fluorous Solid Phase Extraction; FSPE). The FDMTC groups were readily removed by oxidation with m-chloroperbenzoic acid (m-CPBA) and subsequent hydrolysis with KHCO3.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Masaru Kojima, Yutaka Nakamura, Takuma Ishikawa, Seiji Takeuchi,